Antibiotic resistance – An approaching crisis?

Antibiotic drugs are a miracle of modern medicine that we take completely for granted. Well, soon we might not be able to do that any more. Soon, we might be looking back to the amazing time when we didn’t have to think twice about routine surgery because infections could easily be treated. Because with the steady rise of antibiotic resistance, those days might soon be gone. How big a problem is it? And what do we need to do about it?

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References

2:25 Antibiotics: past, present and future, Hutchings et al 2019


4:12 Population genomics and antimicrobial resistance in Corynebacterium diphtheriae, Hennart et al 2020 (growing antibiotic resistance in dipheria)


4:27 Tracking global trends in the effectiveness of antibiotic therapy using the Drug Resistance Index


5:40 Global increase and geographic convergence in antibiotic consumption between 2000 and 2015, Klein et al 2018


6:30 Tackling Drug-Resistant Infections Globally (The UK-commissioned O’Neill report)


7:38 Variable host–pathogen compatibility in Mycobacterium tuberculosis


7:53 Antibiotic overuse: a key driver of antimicrobial resistance


8:28 Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the Global Burden of Disease Study 2016


9:10 Global trends in antimicrobial use in food animals


9:50 Understanding drivers of antibiotic resistance genes in High Arctic soil ecosystems (identifying potential for environmental factors)


13:25 Challenges in Antibiotic R&D Calling for a Global Strategy Considering Both Short- and Long-Term Solutions, Kållberg et al 2019


17:28 Phage as an antimicrobial agent: d’Herelle’s heretical theories and their role in the decline of phage prophylaxis in the West


22:07 Phage Lysins for Fighting Bacterial Respiratory Infections: A New Generation of Antimicrobials


22:54 Treat phage like living antibiotics


24:00 UK testing new pharmaceutical payment system


Additional reading

Crisis Looms in Antibiotics as Drug Makers Go Bankrupt


WHO Global Action Plan on antimicrobial resistance

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